Toosendanin (TSN) is a triterpenoid extracted from Melia toosendan Sieb et Zucc, which was used as a digestive tract-parasiticide and agricultural insecticide in ancient China. TSN was demonstrated to be a selective presynaptic blocker and an effective antibotulismic agent. By interfering with neurotransmitter release through an initial facilitation followed by a subsequent depression, TSN eventually blocks synaptic transmission at both the neuro-muscular junction and central synapses. Despite sharing some similar actions with botulinum neurotoxin (BoNT), TSN has a marked antibotulismic effect in vivo and in vitro.

Studies suggest that the antibotulismic effect of Toosendanin is achieved by preventing BoNT from approaching its enzymatic substrate, the SNARE protein. It is also found that TSN can induce differentiation and apoptosis in several cell lines, and suppress proliferation of various human cancer cells.

English name: Toosendanin

Plant source: It is the active ingredient proposed from the root bark and bark of Neem.

Molecular formula: C30H38O11 Molecular weight: 574.63

Properties: White crystalline powder, melting point 244～245℃ (decomposition). Optical rotation -13.1° (c=1.75, acetone). It is easily soluble in pyridine, acetone, ethanol, methanol, slightly soluble in chloroform, benzene, and almost insoluble in petroleum ether and water.

As a plant-derived insecticide isolated from the bark of Meliaceae and Melia neem, it has stomach toxicity, contact killing and certain antifeedant effects.

1. Prevent and control Lepidopteran pests such as Pieris rapae, Heartworm, Brassica oleracea, Beet Armyworm and other lepidopteran pests.

2. Control aphids

3. Control spider mites

4. Control whitefly on kidney beans

5. Prevention and control of Liriomyza on kidney beans

After the pests eat and come into contact with melidin, it can block the nerve central conduction, destroy the midgut tissue and various detoxification enzymes and respiratory metabolism, affect digestion and absorption, lose the taste function of food, and prevent the pests from growing and developing. Normal and dead.

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We also focus on value-added services. We are available for service questions and information to support your business.

Why Choose Toosendanin?

Green Agri specialize in Toosendanin for sale for several years, we supply products with competitive price, and our product is of the highest quality and undergoes strict, independent testing to ensure that it is safe for consumption around the world.

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